Photoredox activation for the direct β-arylation of ketones and aldehydes

Michael T. Pirnot, Danica A. Rankic, David B.C. Martin, David W.C. MacMillan

Research output: Contribution to journalArticle

315 Scopus citations

Abstract

The direct β-activation of saturated aldehydes and ketones has long been an elusive transformation. We found that photoredox catalysis in combination with organocatalysis can lead to the transient generation of 5π-electron β-enaminyl radicals from ketones and aldehydes that rapidly couple with cyano-substituted aryl rings at the carbonyl β-position. This mode of activation is suitable for a broad range of carbonyl β-functionalization reactions and is amenable to enantioselective catalysis.

Original languageEnglish (US)
Pages (from-to)1593-1596
Number of pages4
JournalScience
Volume340
Issue number6127
DOIs
StatePublished - Mar 29 2013

All Science Journal Classification (ASJC) codes

  • General

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