Photoredox α-vinylation of α-amino acids and N -aryl amines

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Abstract

A new coupling protocol has been developed that allows the union of vinyl sulfones with photoredox-generated α-amino radicals to provide allylic amines of broad diversity. Direct C-H vinylations of N-aryl tertiary amines, as well as decarboxylative vinylations of N-Boc α-amino acids, proceed in high yield and with excellent olefin geometry control. The utility of this new allyl amine forming reaction has been demonstrated via the syntheses of several natural products and a number of established pharmacophores.

Original languageEnglish (US)
Pages (from-to)11602-11605
Number of pages4
JournalJournal of the American Chemical Society
Volume136
Issue number33
DOIs
StatePublished - Aug 20 2014

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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