Photocrosslinking the polystyrene core of block-copolymer nanoparticles

Siyan Zhang, Douglas H. Adamson, Robert K. Prud'Homme, A. James Link

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The crosslinking of the core of nanoparticles composed of polystyrene-block-poly(ethylene oxide) copolymers can be achieved through encapsulation of a small molecule aryl diazide, 4,4′-diazidobiphenyl, and subsequent photolysis. The core-crosslinked nanoparticles exhibited high stability under thermal challenge. These stabilized nanoparticles have potential to serve as a nanobead for the polymerase chain reaction (PCR). We also demonstrated that this crosslinker can endow thin films of polystyrene with solvent resistance. NMR studies on these films provided evidence that crosslinking was occurring via insertion of the nitrene formed by photolysis of the azide into the methylene or methine groups in the backbone of polystyrene.

Original languageEnglish (US)
Pages (from-to)665-671
Number of pages7
JournalPolymer Chemistry
Issue number3
StatePublished - Mar 2011

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Polymers and Plastics
  • Organic Chemistry


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