Aminium radical cations have been extensively studied as electrophilic aminating species that readily participate in C-N bond forming processes with alkenes and arenes. However, their utility in synthesis has been limited, as their generation required unstable, reactive starting materials and harsh reaction conditions. Visible-light photoredox catalysis has emerged as a platform for the mild production of aminium radical cations from either unfunctionalized or N-functionalized amines. This Perspective covers recent synthetic methods that rely on the photocatalytic generation of aminium radical cations for C-N bond formation, specifically in the context of alkene hydroamination, arene C-H bond amination, and the mesolytic bond cleavage of alkoxyamines.
All Science Journal Classification (ASJC) codes
- aminium radical cation
- C-H amination
- electron transfer
- photoredox catalysis