Abstract
Aminium radical cations have been extensively studied as electrophilic aminating species that readily participate in C-N bond forming processes with alkenes and arenes. However, their utility in synthesis has been limited, as their generation required unstable, reactive starting materials and harsh reaction conditions. Visible-light photoredox catalysis has emerged as a platform for the mild production of aminium radical cations from either unfunctionalized or N-functionalized amines. This Perspective covers recent synthetic methods that rely on the photocatalytic generation of aminium radical cations for C-N bond formation, specifically in the context of alkene hydroamination, arene C-H bond amination, and the mesolytic bond cleavage of alkoxyamines.
Original language | English (US) |
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Pages (from-to) | 11712-11738 |
Number of pages | 27 |
Journal | ACS Catalysis |
Volume | 10 |
Issue number | 20 |
DOIs | |
State | Published - Oct 16 2020 |
All Science Journal Classification (ASJC) codes
- General Chemistry
- Catalysis
Keywords
- C-H amination
- aminium radical cation
- electron transfer
- hydroamination
- photoredox catalysis