Photobiocatalytic Strategies for Organic Synthesis

Megan A. Emmanuel, Sophie G. Bender, Catherine Bilodeau, Jose M. Carceller, Jacob S. DeHovitz, Haigen Fu, Yi Liu, Bryce T. Nicholls, Yao Ouyang, Claire G. Page, Tianzhang Qiao, Felix C. Raps, Damien R. Sorigué, Shang Zheng Sun, Joshua Turek-Herman, Yuxuan Ye, Ariadna Rivas-Souchet, Jingzhe Cao, Todd K. Hyster

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Biocatalysis has revolutionized chemical synthesis, providing sustainable methods for preparing various organic molecules. In enzyme-mediated organic synthesis, most reactions involve molecules operating from their ground states. Over the past 25 years, there has been an increased interest in enzymatic processes that utilize electronically excited states accessed through photoexcitation. These photobiocatalytic processes involve a diverse array of reaction mechanisms that are complementary to one another. This comprehensive review will describe the state-of-the-art strategies in photobiocatalysis for organic synthesis until December 2022. Apart from reviewing the relevant literature, a central goal of this review is to delineate the mechanistic differences between the general strategies employed in the field. We will organize this review based on the relationship between the photochemical step and the enzymatic transformations. The review will include mechanistic studies, substrate scopes, and protein optimization strategies. By clearly defining mechanistically-distinct strategies in photobiocatalytic chemistry, we hope to illuminate future synthetic opportunities in the area.

Original languageEnglish (US)
Pages (from-to)5459-5520
Number of pages62
JournalChemical Reviews
Issue number9
StatePublished - May 10 2023
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Chemistry


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