Photoacoustic assessment of nanoparticles distribution pattern in the mouse brain following blood-brain barrier (BBB) disruption

Johann Le Floc'H, Hoang D. Lu, Christine Demore, Robert K. Prud'Homme, Kullervo Hynynen, F. Stuart Foster

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Focused ultrasound (FUS) with circulating microbubbles creates transient and reversible permeabilization of vasculatures which provides an essential means to deliver therapeutics and imaging agents, for instance across the BBB. We have previously shown that 3D color Doppler and photoacoustic imaging can monitor BBB disruption (BBBD) in mice. Here we study how changes in NPs size, concentration and dye properties play an important role in their spatial deposition.

Original languageEnglish (US)
Title of host publication2017 IEEE International Ultrasonics Symposium, IUS 2017
PublisherIEEE Computer Society
ISBN (Electronic)9781538633830
DOIs
StatePublished - Oct 31 2017
Event2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States
Duration: Sep 6 2017Sep 9 2017

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2017 IEEE International Ultrasonics Symposium, IUS 2017
CountryUnited States
CityWashington
Period9/6/179/9/17

All Science Journal Classification (ASJC) codes

  • Acoustics and Ultrasonics

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