Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis

Suet Y. Leung, Xin Chen, Kent M. Chu, Siu T. Yuen, Jonathan Mathy, Jiafu Ji, Annie S.Y. Chan, Rui Li, Simon Law, Olga G. Troyanskaya, I. Ping Tu, John Wong, Samuel So, David Botstein, Patrick O. Brown

Research output: Contribution to journalArticle

147 Scopus citations

Abstract

We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing ≈30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the ApcMin/+ (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly correlated with patient survival. We confirmed this observation in an independent set of patient samples by using quantitative RT-PCR. Beyond its potential diagnostic and prognostic significance, this result suggests the intriguing possibility that the activity of PLA2G2A may suppress progression or metastasis of human gastric cancer.

Original languageEnglish (US)
Pages (from-to)16203-16208
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume99
Issue number25
DOIs
StatePublished - Dec 10 2002

All Science Journal Classification (ASJC) codes

  • General

Keywords

  • DNA microarray
  • Gastritis
  • Gene expression profiling
  • Helicobacter
  • Mucosal immunity

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    Leung, S. Y., Chen, X., Chu, K. M., Yuen, S. T., Mathy, J., Ji, J., Chan, A. S. Y., Li, R., Law, S., Troyanskaya, O. G., Tu, I. P., Wong, J., So, S., Botstein, D., & Brown, P. O. (2002). Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis. Proceedings of the National Academy of Sciences of the United States of America, 99(25), 16203-16208. https://doi.org/10.1073/pnas.212646299