Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis

Suet Y. Leung; Xin Chen; Kent M. Chu; Siu T. Yuen; Jonathan Mathy; Jiafu Ji; Annie S.Y. Chan; Rui Li; Simon Law; Olga G. Troyanskaya; I. Ping Tu; John Wong; Samuel So; David Botstein; Patrick O. Brown

doi:10.1073/pnas.212646299

Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis

Suet Y. Leung, Xin Chen, Kent M. Chu, Siu T. Yuen, Jonathan Mathy, Jiafu Ji, Annie S.Y. Chan, Rui Li, Simon Law, Olga G. Troyanskaya, I. Ping Tu, John Wong, Samuel So, David Botstein, Patrick O. Brown

Research output: Contribution to journal › Article › peer-review

177 Scopus citations

Abstract

We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing ≈30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the Apc^Min/+ (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly correlated with patient survival. We confirmed this observation in an independent set of patient samples by using quantitative RT-PCR. Beyond its potential diagnostic and prognostic significance, this result suggests the intriguing possibility that the activity of PLA2G2A may suppress progression or metastasis of human gastric cancer.

Original language	English (US)
Pages (from-to)	16203-16208
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	99
Issue number	25
DOIs	https://doi.org/10.1073/pnas.212646299
State	Published - Dec 10 2002

All Science Journal Classification (ASJC) codes

General

Keywords

DNA microarray
Gastritis
Gene expression profiling
Helicobacter
Mucosal immunity

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10.1073/pnas.212646299

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Leung, S. Y., Chen, X., Chu, K. M., Yuen, S. T., Mathy, J., Ji, J., Chan, A. S. Y., Li, R., Law, S., Troyanskaya, O. G., Tu, I. P., Wong, J., So, S., Botstein, D., & Brown, P. O. (2002). Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis. Proceedings of the National Academy of Sciences of the United States of America, 99(25), 16203-16208. https://doi.org/10.1073/pnas.212646299

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title = "Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis",

abstract = "We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing ≈30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the ApcMin/+ (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly correlated with patient survival. We confirmed this observation in an independent set of patient samples by using quantitative RT-PCR. Beyond its potential diagnostic and prognostic significance, this result suggests the intriguing possibility that the activity of PLA2G2A may suppress progression or metastasis of human gastric cancer.",

keywords = "DNA microarray, Gastritis, Gene expression profiling, Helicobacter, Mucosal immunity",

author = "Leung, {Suet Y.} and Xin Chen and Chu, {Kent M.} and Yuen, {Siu T.} and Jonathan Mathy and Jiafu Ji and Chan, {Annie S.Y.} and Rui Li and Simon Law and Troyanskaya, {Olga G.} and Tu, {I. Ping} and John Wong and Samuel So and David Botstein and Brown, {Patrick O.}",

year = "2002",

month = dec,

day = "10",

doi = "10.1073/pnas.212646299",

language = "English (US)",

volume = "99",

pages = "16203--16208",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

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Leung, SY, Chen, X, Chu, KM, Yuen, ST, Mathy, J, Ji, J, Chan, ASY, Li, R, Law, S, Troyanskaya, OG, Tu, IP, Wong, J, So, S, Botstein, D & Brown, PO 2002, 'Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis', Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 25, pp. 16203-16208. https://doi.org/10.1073/pnas.212646299

Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis. / Leung, Suet Y.; Chen, Xin; Chu, Kent M. et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 25, 10.12.2002, p. 16203-16208.

Research output: Contribution to journal › Article › peer-review

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T1 - Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis

AU - Leung, Suet Y.

AU - Chen, Xin

AU - Chu, Kent M.

AU - Yuen, Siu T.

AU - Mathy, Jonathan

AU - Ji, Jiafu

AU - Chan, Annie S.Y.

AU - Li, Rui

AU - Law, Simon

AU - Troyanskaya, Olga G.

AU - Tu, I. Ping

AU - Wong, John

AU - So, Samuel

AU - Botstein, David

AU - Brown, Patrick O.

PY - 2002/12/10

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N2 - We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing ≈30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the ApcMin/+ (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly correlated with patient survival. We confirmed this observation in an independent set of patient samples by using quantitative RT-PCR. Beyond its potential diagnostic and prognostic significance, this result suggests the intriguing possibility that the activity of PLA2G2A may suppress progression or metastasis of human gastric cancer.

AB - We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing ≈30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the ApcMin/+ (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly correlated with patient survival. We confirmed this observation in an independent set of patient samples by using quantitative RT-PCR. Beyond its potential diagnostic and prognostic significance, this result suggests the intriguing possibility that the activity of PLA2G2A may suppress progression or metastasis of human gastric cancer.

KW - DNA microarray

KW - Gastritis

KW - Gene expression profiling

KW - Helicobacter

KW - Mucosal immunity

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Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis

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