Pharmacology of the cardiovascular system

Naomi B. Bishop; Bruce M. Greenwald; Daniel A. Notterman

doi:10.1016/B978-0-323-67269-6.00040-0

Pharmacology of the cardiovascular system

Naomi B. Bishop
, Bruce M. Greenwald
, Daniel A. Notterman

Molecular Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Cardiovascular dysfunction is a cardinal manifestation of critical illness in children. Pediatric intensivists must have a solid understanding of the basic science and practice aspects of drugs used to treat these disorders. Therefore, a thorough understanding of cardiovascular pharmacology—including the indications, clinical effects, pharmacokinetics, pharmacodynamics, adverse reactions, and drug interactions—is essential to ensure optimal outcomes with minimal risk. This chapter offers an overview of the clinical pharmacology of the five catecholamines, two noncatecholamine agents, and the venerable cardiac glycosides most commonly used to support critically ill children..

Original language	English (US)
Title of host publication	Fuhrman and Zimmerman's Pediatric Critical Care
Publisher	Elsevier
Pages	300-319.e7
ISBN (Electronic)	9780323672696
ISBN (Print)	9780323378390
DOIs	https://doi.org/10.1016/B978-0-323-67269-6.00040-0
State	Published - Jan 1 2021

All Science Journal Classification (ASJC) codes

General Medicine

Keywords

adrenergic receptors
bipyridines
catecholamines
epinephrine
inotropes
milrinone
norepinephrine
phosphodiesterase inhibitor
Shock
vasoactive drugs
vasopressin

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10.1016/B978-0-323-67269-6.00040-0

Cite this

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AU - Bishop, Naomi B.

AU - Greenwald, Bruce M.

AU - Notterman, Daniel A.

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AB - Cardiovascular dysfunction is a cardinal manifestation of critical illness in children. Pediatric intensivists must have a solid understanding of the basic science and practice aspects of drugs used to treat these disorders. Therefore, a thorough understanding of cardiovascular pharmacology—including the indications, clinical effects, pharmacokinetics, pharmacodynamics, adverse reactions, and drug interactions—is essential to ensure optimal outcomes with minimal risk. This chapter offers an overview of the clinical pharmacology of the five catecholamines, two noncatecholamine agents, and the venerable cardiac glycosides most commonly used to support critically ill children..

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KW - bipyridines

KW - catecholamines

KW - epinephrine

KW - inotropes

KW - milrinone

KW - norepinephrine

KW - phosphodiesterase inhibitor

KW - Shock

KW - vasoactive drugs

KW - vasopressin

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DO - 10.1016/B978-0-323-67269-6.00040-0

M3 - Chapter

AN - SCOPUS:105033402516

SN - 9780323378390

SP - 300-319.e7

BT - Fuhrman and Zimmerman's Pediatric Critical Care

PB - Elsevier

ER -

Pharmacology of the cardiovascular system

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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