Pharmacology and reflex responsiveness of the heart in the giant garden slug, Limax maximus

Alexander R. MacKay; Alan Gelperin

doi:10.1016/0300-9629(72)90160-0

Pharmacology and reflex responsiveness of the heart in the giant garden slug, Limax maximus

Alexander R. MacKay, Alan Gelperin

Princeton Neuroscience Institute

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

1. 1. The anatomy and innervation of the heart in the slug Limax maximus are described. 2. 2. The heart is myogenic and is reflexively modulated by tactile stimulation of the body surface. 3. 3. Pharmacological data suggest that cardioexcitation is serotoninergic and cardioinhibition cholinergic, although both ACh and 5-HT have biphasic effects depending on concentration. 4. 4. Cardioexcitatory and cardioinhibitory areas of the visceral ganglion were identified and modulation of heart rate by single cells demonstrated.

Original language	English (US)
Pages (from-to)	877-896
Number of pages	20
Journal	Comparative Biochemistry and Physiology -- Part A: Physiology
Volume	43
Issue number	4
DOIs	https://doi.org/10.1016/0300-9629(72)90160-0
State	Published - Dec 1 1972

All Science Journal Classification (ASJC) codes

Physiology

Keywords

Limax maximus
Slug heart
acetylcholine
pharmacology of slug heart
serotonin

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10.1016/0300-9629(72)90160-0

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abstract = "1. 1. The anatomy and innervation of the heart in the slug Limax maximus are described. 2. 2. The heart is myogenic and is reflexively modulated by tactile stimulation of the body surface. 3. 3. Pharmacological data suggest that cardioexcitation is serotoninergic and cardioinhibition cholinergic, although both ACh and 5-HT have biphasic effects depending on concentration. 4. 4. Cardioexcitatory and cardioinhibitory areas of the visceral ganglion were identified and modulation of heart rate by single cells demonstrated.",

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AU - Gelperin, Alan

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N2 - 1. 1. The anatomy and innervation of the heart in the slug Limax maximus are described. 2. 2. The heart is myogenic and is reflexively modulated by tactile stimulation of the body surface. 3. 3. Pharmacological data suggest that cardioexcitation is serotoninergic and cardioinhibition cholinergic, although both ACh and 5-HT have biphasic effects depending on concentration. 4. 4. Cardioexcitatory and cardioinhibitory areas of the visceral ganglion were identified and modulation of heart rate by single cells demonstrated.

AB - 1. 1. The anatomy and innervation of the heart in the slug Limax maximus are described. 2. 2. The heart is myogenic and is reflexively modulated by tactile stimulation of the body surface. 3. 3. Pharmacological data suggest that cardioexcitation is serotoninergic and cardioinhibition cholinergic, although both ACh and 5-HT have biphasic effects depending on concentration. 4. 4. Cardioexcitatory and cardioinhibitory areas of the visceral ganglion were identified and modulation of heart rate by single cells demonstrated.

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KW - Slug heart

KW - acetylcholine

KW - pharmacology of slug heart

KW - serotonin

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JO - Comparative Biochemistry and Physiology -- Part A: Physiology

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Pharmacology and reflex responsiveness of the heart in the giant garden slug, Limax maximus

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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