PertInInt: An Integrative, Analytical Approach to Rapidly Uncover Cancer Driver Genes with Perturbed Interactions and Functionalities

Keyphrases

• Somatic mutation 100%
• Analytical Approach 100%
• Cancer Driver Genes 100%
• Small Molecules 50%
• Tumor 50%
• In Cancer 50%
• Functional Role 50%
• Analytical Calculation 50%
• Gene Level 50%
• Mechanism of Action 50%
• Cancer Genomics 50%
• Multiple Measures 50%
• Role in Cancer 50%
• Integrative Framework 50%
• Cancer Genes 50%
• Tumor Samples 50%
• Evolutionary Conservation 50%
• Relevant Genes 50%
• Interaction Domains 50%
• Interaction with DNA 50%
• Functional Site 50%
• Mutation Data 50%
• Ion-molecule 50%
• Peptide Ions 50%
• Permutation-based 50%
• Conservation Level 50%
• Interaction Sites 50%
• Major Challenges 50%
• Interaction Types 50%

Biochemistry, Genetics and Molecular Biology

• Somatic Mutation 100%
• Small Molecule 50%
• DNA RNA Hybridization 50%
• Oncogene 50%
• Genetic Conservation 50%
• Interactions with DNA 50%
• Peptide 50%
• Cancer Genomics 50%