@article{9d6475bc70e34c92b18ff7fc8a5a302f,
title = "Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example",
abstract = "This commentary was written as a collaboration between the Board of the Metastasis Research Society and two patients with metastatic breast cancer. It was conceived in response to how preclinical scientific research is sometimes presented to non-scientists in a way that can cause stress and confusion. Translation of preclinical findings to the clinic requires overcoming multiple barriers. This is irrespective of whether the findings relate to exciting responses to new therapies or problematic effects of currently used therapies. It is important that these barriers are understood and acknowledged when research findings are summarized for mainstream reporting. To minimize confusion, patients should continue to rely on their oncology care team to help them interpret whether research findings presented in mainstream media have relevance for their individual care. Researchers, both bench and clinical, should work together where possible to increase options for patients with metastatic disease, which is still in desperate need of effective therapeutic approaches.",
keywords = "Metastatic progression, Neoadjuvant chemotherapy, Relapse, Survival",
author = "{on behalf of the Board of the Metastasis Research Society} and Barbara Fingleton and Kelly Lange and Beth Caldwell and Bankaitis, {Katherine V.} and Yibin Kang and Dihua Yu and Julio Aguirre-Ghiso and Cox, {Thomas R.} and Erler, {Janine T.} and Gelman, {Irwin H.} and Hurst, {Douglas R.} and Yasumasa Kato and Lynch, {Conor C.} and Price, {John T.} and Samant, {Rajeev S.} and Jonathan Sleeman and Ulrike Stein and Andries Zijlstra",
note = "Funding Information: Beth Caldwell, an author of this piece, died from her disease before publication. We honor Beth by dedicating this piece to her memory and by continuing to work to overcome metastatic disease. Members of the Board of the Metastasis Research Society are Yibin Kang (Department of Molecular Biology, Princeton University, Princeton, NJ, USA); Dihua Yu (Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA); Julio Aguirre-Ghiso (Department of Medicine and Department of Otolaryngology, Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, NY, USA); Thomas R. Cox (The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Cancer Division, St Vincent{\textquoteright}s Clinical School, Faculty of Medicine, UNSW Sydney, NSW 2010, Australia); Janine T. Erler (Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark); Irwin H. Gelman (Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA); Douglas R. Hurst (Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA); Yasumasa Kato (Department of Oral Function and Molecular Biology, Ohu University School of Dentistry, Koriyama, Japan); Conor C. Lynch (Tumor Biology Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; John T. Price, College of Health and Biomedicine, Victoria University, St Albans, Victoria, Australia); Rajeev S. Samant (Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA); Jonathan Sleeman (Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany); Ulrike Stein (Experimental and Clinical Research Center, Charit{\'e} – Universit{\"a}tsmedizin and Max-Delbr{\"u}ck-Center for Molecular Medicine Berlin, Berlin, Germany); Andries Zijlstra (Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA). Members of the Board of the Metastasis Research Society are listed in “Acknowledgments”. Deceased—Beth Caldwell. No conflicts of interest to declare. Publisher Copyright: {\textcopyright} 2018, Springer Science+Business Media B.V., part of Springer Nature.",
year = "2017",
month = dec,
day = "1",
doi = "10.1007/s10585-017-9872-8",
language = "English (US)",
volume = "34",
pages = "443--447",
journal = "Clinical and Experimental Metastasis",
issn = "0262-0898",
publisher = "Springer Netherlands",
number = "8",
}