Persistent neural activity: Prevalence and mechanisms

Guy Major, David Tank

Research output: Contribution to journalReview articlepeer-review

236 Scopus citations


Persistent neural activity refers to a sustained change in action potential discharge that long outlasts a stimulus. It is found in a diverse set of brain regions and organisms and several in vitro systems, suggesting that it can be considered a universal form of circuit dynamics that can be used as a mechanism for short-term storage and accumulation of sensory or motor information. Both single cell and network mechanisms are likely to co-operate in generating persistent activity in many brain areas.

Original languageEnglish (US)
Pages (from-to)675-684
Number of pages10
JournalCurrent Opinion in Neurobiology
Issue number6
StatePublished - Dec 2004

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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