TY - JOUR
T1 - Peroxisome Plasticity at the Virus–Host Interface
AU - Cook, Katelyn C.
AU - Moreno, Jorge A.
AU - Jean Beltran, Pierre M.
AU - Cristea, Ileana M.
N1 - Funding Information:
We are grateful for funding from the National Institutes for Health ( NIH ) ( R01 GM114141 ) and Mallinckrodt Scholar Award to I.M.C., as well as an NIH training grant from National Institute of General Medical Sciences ( NIGMS ) ( T32GM007388 ).
Publisher Copyright:
© 2019
PY - 2019/11
Y1 - 2019/11
N2 - Peroxisomes are multifunctional organelles with roles in cellular metabolism, cytotoxicity, and signaling. The plastic nature of these organelles allows them to respond to diverse biological processes, such as virus infections, by remodeling their biogenesis, morphology, and composition to enhance specific functions. During virus infections in humans, peroxisomes act as important immune signaling organelles, aiding the host by orchestrating antiviral signaling. However, more recently it was discovered that peroxisomes can also benefit the virus, facilitating virus–host interactions that rewire peroxisomes to support cellular processes for virus replication and spread. Here, we describe recent studies that uncovered this double-edged character of peroxisomes during infection, highlighting mechanisms that viruses have coevolved to take advantage of peroxisome plasticity. We also provide a perspective for future studies by comparing the established roles of peroxisomes in plant infections and discussing the promise of virology studies as a venue to reveal the uncharted biology of peroxisomes.
AB - Peroxisomes are multifunctional organelles with roles in cellular metabolism, cytotoxicity, and signaling. The plastic nature of these organelles allows them to respond to diverse biological processes, such as virus infections, by remodeling their biogenesis, morphology, and composition to enhance specific functions. During virus infections in humans, peroxisomes act as important immune signaling organelles, aiding the host by orchestrating antiviral signaling. However, more recently it was discovered that peroxisomes can also benefit the virus, facilitating virus–host interactions that rewire peroxisomes to support cellular processes for virus replication and spread. Here, we describe recent studies that uncovered this double-edged character of peroxisomes during infection, highlighting mechanisms that viruses have coevolved to take advantage of peroxisome plasticity. We also provide a perspective for future studies by comparing the established roles of peroxisomes in plant infections and discussing the promise of virology studies as a venue to reveal the uncharted biology of peroxisomes.
KW - herpesvirus
KW - host–pathogen interactions
KW - innate immunity
KW - organelle remodeling
KW - peroxisome
KW - virus
KW - virus–host interactions
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U2 - 10.1016/j.tim.2019.06.006
DO - 10.1016/j.tim.2019.06.006
M3 - Review article
C2 - 31331665
AN - SCOPUS:85069545739
SN - 0966-842X
VL - 27
SP - 906
EP - 914
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 11
ER -