Performance of an exhaled nitric oxide and carbon dioxide sensor using quantum cascade laser-based integrated cavity output spectroscopy

Matthew R. McCurdy, Yury Bakhirkin, Gerard Wysocki, Frank K. Tittel

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Exhaled nitric oxide (NO) is an important biomarker in asthma and other respiratory disorders. The optical performance of a NO/CO2 sensor employing integrated cavity output spectroscopy (ICOS) with a quantum cascade laser operating at 5.22 μm capable of real-time NO and CO2 measurements in a single breath cycle is reported. A NO noise-equivalent concentration of 0.4 ppb within a 1-sec integration time is achieved. The off-axis ICOS sensor performance is compared to a chemiluminescent NO analyzer and a nondispersive infrared (NDIR) CO2 absorption capnograph. Differences between the gas analyzers are assessed by the Bland-Altman method to estimate the expected variability between the gas sensors. The off-axis ICOS sensor measurements are in good agreement with the data acquired with the two commercial gas analyzers. This work demonstrates the performance characteristics and merits of mid-infrared spectroscopy for exhaled breath analysis.

Original languageEnglish (US)
Article number034034
JournalJournal of Biomedical Optics
Volume12
Issue number3
DOIs
StatePublished - May 1 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Keywords

  • Breath analysis
  • Carbon dioxide
  • Chemiluminescence
  • Integrated cavity output spectroscopy
  • Nitric oxide
  • Quantum cascade laser

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