TY - JOUR
T1 - Perceived stress and biological risk
T2 - Is the link stronger in Russians than in Taiwanese and Americans?
AU - Glei, Dana A.
AU - Goldman, Noreen
AU - Shkolnikov, Vladimir M.
AU - Jdanov, Dmitri
AU - Shkolnikova, Maria
AU - Vaupel, James W.
AU - Weinstein, Maxine
N1 - Funding Information:
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. This work was supported by the National Institute on Aging (grant numbers R01AG026786, R01AG16790, R01AG16661, P01-AG020166), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (grant number R24HD047879) and the Dynasty Foundation (Russia).
Funding Information:
Funding for the TLSA came from the Taiwan Department of Health, the Taiwan National Health Research Institute [grant number DD01-86IX-GR601S] and the Taiwan Provincial Government. SEBAS was funded by the Demography and Epidemiology Unit of the Behavioral and Social Research Program of the National Institute on Aging [grant numbers R01 AG16790, R01 AG16661]. The Bureau of Health Promotion (BHP, Department of Health, Taiwan) provided additional financial support for SEBAS 2000.
Funding Information:
The original MIDUS study was supported by the MacArthur Foundation Research Network on Successful Midlife Development. The MIDUS longitudinal follow-up was supported by the National Institute on Aging [grant number P01-AG020166]. The specimen collection was also facilitated by the General Clinical Research Centers Program [grant numbers M01-RR023942 to Georgetown University; M01-RR00865 to UCLA] and by the Clinical and Translational Science Award program of the National Center for Research Resources, National Institutes of Health [grant number 1UL1RR025011 to University of Wisconsin-Madison].
PY - 2013/7
Y1 - 2013/7
N2 - Allostatic load theory implies a relationship between exposure to psychological stress and multi-system physiological dysregulation. We used data from population-based samples of men and women in Russia (Moscow; n=1800; age, mean 68.6 years), Taiwan (n=1036; 65.6 years) and the United States (US; n=1054; 58.0 years)-which are likely to vary widely with respect to levels of stress exposure and biological markers-to determine the magnitude of the association between perceived stress and physiological dysregulation. The measure of overall dysregulation was based on 15 markers including standard cardiovascular/ metabolic risk factors as well as markers of inflammation and neuroendocrine activity. Subjective psychological stress was measured by the perceived stress scale. Only the Moscow sample demonstrated a positive association with overall dysregulation in both sexes. In the US, we found an association among women but not men. Among the Taiwanese, who report the lowest perceived stress, there was no association in women but an unexpected inverse relationship in men. The effects also varied across system-level subscores: the association with perceived stress was most consistent for standard cardiovascular/metabolic factors. Perceived stress was associated with inflammation and neuroendocrine activity in some samples. Although the evidence that perceived stress is the primary source of physiological dysregulation is generally modest, it was stronger in Russia where the level of perceived stress was particularly high. For Russia only, we had information about heart function based on a 24h ambulatory electrocardiogram; perceived stress was consistently associated with heart rate dysregulation in Russian men and women.
AB - Allostatic load theory implies a relationship between exposure to psychological stress and multi-system physiological dysregulation. We used data from population-based samples of men and women in Russia (Moscow; n=1800; age, mean 68.6 years), Taiwan (n=1036; 65.6 years) and the United States (US; n=1054; 58.0 years)-which are likely to vary widely with respect to levels of stress exposure and biological markers-to determine the magnitude of the association between perceived stress and physiological dysregulation. The measure of overall dysregulation was based on 15 markers including standard cardiovascular/ metabolic risk factors as well as markers of inflammation and neuroendocrine activity. Subjective psychological stress was measured by the perceived stress scale. Only the Moscow sample demonstrated a positive association with overall dysregulation in both sexes. In the US, we found an association among women but not men. Among the Taiwanese, who report the lowest perceived stress, there was no association in women but an unexpected inverse relationship in men. The effects also varied across system-level subscores: the association with perceived stress was most consistent for standard cardiovascular/metabolic factors. Perceived stress was associated with inflammation and neuroendocrine activity in some samples. Although the evidence that perceived stress is the primary source of physiological dysregulation is generally modest, it was stronger in Russia where the level of perceived stress was particularly high. For Russia only, we had information about heart function based on a 24h ambulatory electrocardiogram; perceived stress was consistently associated with heart rate dysregulation in Russian men and women.
KW - Allostatic load
KW - Biological markers
KW - Cardiovascular risk factors
KW - Heart function
KW - Inflammatory markers
KW - Physiological dysregulation
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U2 - 10.3109/10253890.2013.789015
DO - 10.3109/10253890.2013.789015
M3 - Article
C2 - 23534869
AN - SCOPUS:84879108453
SN - 1025-3890
VL - 16
SP - 411
EP - 420
JO - Stress
JF - Stress
IS - 4
ER -