The ability to assemble a target protein from a series of peptide fragments, either synthetic or biosynthetic in origin, enables the covalent structure of a protein to be modified in an unprecedented fashion. The present technologies available for performing such peptide ligations are discussed, with an emphasis on how these methodologies have been utilized in protein engineering to investigate biological processes.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Molecular Medicine
- Molecular Biology
- Clinical Biochemistry