Peak-tracking chip" (PTC) for bulk refractive index sensing and bioarray sensing

Kristelle Bougot-Robin, Shunbo Li, Yinghua Zhang, Rimantas Kodzius, I. Ming Hsing, Henri Benisty, Robert H. Austin, Weijia Wen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Resonant techniques are of wide interest to detect variation of effective refractive index at a chip surface. Both Surface Plasmon Resonance (SPR) and dielectric resonant waveguide (RWGs) can be exploited. Through their design, RWGs allow more flexibility (size of the biomolecule to detect, detection angle...). Using specially designed RWG "Peak-tracking chip", we propose to use spatial information from a simple monochromatic picture as a new label-free bioarray technique. We discuss robustness, sensitivity, multiplex detection, fluidic integration of the technique and illustrate it through bulk refractive index sensing as well as specific recognition of DNA fragment from gyrase A.

Original languageEnglish (US)
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages1324-1326
Number of pages3
ISBN (Print)9780979806452
StatePublished - Jan 1 2012
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: Oct 28 2012Nov 1 2012

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
CountryJapan
CityOkinawa
Period10/28/1211/1/12

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Keywords

  • Bioarray imaging
  • Grating
  • Label-free
  • Refractive index sensing
  • Resonance

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