Abstract
The direct, Pd-catalyzed ortho C-H methylation and fluorination of benzaldehydes have been accomplished using commercially available orthanilic acids as transient directing groups. In these reactions, the 1-fluoro-2,4,6-trimethylpyridinium salts can be either a bystanding F+ oxidant or an electrophilic fluorinating reagent. An X-ray crystal structure of a benzaldehyde ortho C-H palladation intermediate was obtained using triphenylphosphine as the stabilizing ligand.
Original language | English (US) |
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Pages (from-to) | 2789-2792 |
Number of pages | 4 |
Journal | Journal of the American Chemical Society |
Volume | 140 |
Issue number | 8 |
DOIs | |
State | Published - Feb 28 2018 |
All Science Journal Classification (ASJC) codes
- General Chemistry
- Biochemistry
- Catalysis
- Colloid and Surface Chemistry