Paused RNA polymerase II as a developmental checkpoint

Research output: Contribution to journalReview article

182 Scopus citations

Abstract

The textbook view of gene activation is that the rate-limiting step is the interaction of RNA polymerase II (Pol II) with the gene's promoter. However, studies in a variety of systems, including human embryonic stem cells and the early Drosophila embryo, have begun to challenge this view. There is increasing evidence that differential gene expression often depends on the regulation of transcription elongation via the release of Pol II from the proximal promoter. I review the implications of this mechanism of gene activation with respect to the orderly unfolding of complex gene networks governing animal development.

Original languageEnglish (US)
Pages (from-to)502-511
Number of pages10
JournalCell
Volume145
Issue number4
DOIs
StatePublished - May 13 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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