Parallel quorum sensing systems converge to regulate virulence in Vibrio cholerae

Melissa B. Miller, Karen Skorupski, Derrick H. Lenz, Ronald K. Taylor, Bonnie L. Bassler

Research output: Contribution to journalArticle

451 Scopus citations

Abstract

The marine bacterium Vibrio harveyi possesses two quorum sensing systems (System 1 and System 2) that regulate bioluminescence. Although the Vibrio cholerae genome sequence reveals that a V. harveyi-like System 2 exists, it does not predict the existence of a V. harveyi-like System 1 or any obvious quorum sensing-controlled target genes. In this report we identify and characterize the genes encoding an additional V. cholerae autoinducer synthase and its cognate sensor. Analysis of double mutants indicates that a third as yet unidentified sensory circuit exists in V. cholerae. This quorum sensing apparatus is unusually complex, as it is composed of at least three parallel signaling channels. We show that in V. cholerae these communication systems converge to control virulence.

Original languageEnglish (US)
Pages (from-to)303-314
Number of pages12
JournalCell
Volume110
Issue number3
DOIs
StatePublished - Aug 9 2002

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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