Hexane is particularly favorable as a solvent for hydrostannylation of hindered internal alkynes by minimizing the competing formation of H2 and Bu3SnSnBu3. The optimum conditions involve Pd(OAc)2 and a donor monophosphine (PCy3) in hexane at 23°C.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry