Palladium catalyzed diastereoselective addition of secondary alcohols to acyloxyazetidinones

Ann Marie Madar, Guy R. Humphrey, Andrew S. Thompson, Thomas R. Verhoeven, Paul J. Reider

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Palladium catalyzed addition of lactate esters or phenethyl alcohols to acyloxyazetidinones gives 4-oxy-substituted β-lactams with 6-9:1 diastereoselectivity. The stereochemistry of the major products was established as S*S* by X-ray crystallography.

Original languageEnglish (US)
Pages (from-to)2393-2396
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number11
DOIs
StatePublished - Nov 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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