Palladium-catalyzed allylic C-H fluorination

Marie Gabrielle Braun, Abigail G. Doyle

Research output: Contribution to journalArticle

139 Scopus citations

Abstract

The first catalytic allylic C-H fluorination reaction using a nucleophilic fluoride source is reported. Under the influence of a Pd/Cr cocatalyst system, simple olefin substrates undergo fluorination with Et3N·3HF in good yields with high branched:linear regioselectivity. The mild conditions and broad scope make this reaction a powerful alternative to established methods for the preparation of allylic fluorides from prefunctionalized substrates.

Original languageEnglish (US)
Pages (from-to)12990-12993
Number of pages4
JournalJournal of the American Chemical Society
Volume135
Issue number35
DOIs
StatePublished - Sep 4 2013

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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