7-Substituted bicyclo[3.2.0]hept-2-en-6-one derivatives were identified as intermediates towards biologically interesting compounds. An improved synthesis of 7-alkyl-7-bromobicyclo[3.2.0]hept-2-en-6-ones by palladium- catalysed [π2a+π2s] cycloaddition of α-bromoalkyl ketenes to cyclopentadiene is described. Increased yields and increasing exo alkyl cycloadducts were observed with various palladium catalysts under standard dehydrochlorination conditions. (C) 2000 Elsevier Science Ltd.
|Original language||English (US)|
|Number of pages||4|
|State||Published - May 6 2000|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry
- Bicyclic aliphatic compounds