Paip2 is localized to active promoters and loaded onto nascent mRNA in Drosophila

Zaur M. Kachaev, Lyubov A. Lebedeva, Eugene N. Kozlov, Ilya Y. Toropygin, Paul Schedl, Yulii V. Shidlovskii

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Paip2 (Poly(A)-binding protein–interacting protein 2) is a conserved metazoan-specific protein that has been implicated in regulating the translation and stability of mRNAs. However, we have found that Paip2 is not restricted to the cytoplasm but is also found in the nucleus in Drosophila embryos, salivary glands, testes, and tissue culture cells. Nuclear Paip2 is associated with chromatin, and in chromatin immunoprecipitation experiments it maps to the promoter regions of active genes. However, this chromatin association is indirect, as it is RNA-dependent. Thus, Paip2 is one more item in the growing list of translation factors that are recruited to mRNAs co-transcriptionally.

Original languageEnglish (US)
Pages (from-to)1708-1720
Number of pages13
JournalCell Cycle
Issue number14
StatePublished - Jul 18 2018

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology
  • Developmental Biology


  • Paip2
  • mRNA
  • nucleus
  • promoter
  • transcription


Dive into the research topics of 'Paip2 is localized to active promoters and loaded onto nascent mRNA in Drosophila'. Together they form a unique fingerprint.

Cite this