@article{83f59536265c42a49c751d1b33dbd517,
title = "Paip2 is localized to active promoters and loaded onto nascent mRNA in Drosophila",
abstract = "Paip2 (Poly(A)-binding protein–interacting protein 2) is a conserved metazoan-specific protein that has been implicated in regulating the translation and stability of mRNAs. However, we have found that Paip2 is not restricted to the cytoplasm but is also found in the nucleus in Drosophila embryos, salivary glands, testes, and tissue culture cells. Nuclear Paip2 is associated with chromatin, and in chromatin immunoprecipitation experiments it maps to the promoter regions of active genes. However, this chromatin association is indirect, as it is RNA-dependent. Thus, Paip2 is one more item in the growing list of translation factors that are recruited to mRNAs co-transcriptionally.",
keywords = "Paip2, mRNA, nucleus, promoter, transcription",
author = "Kachaev, {Zaur M.} and Lebedeva, {Lyubov A.} and Kozlov, {Eugene N.} and Toropygin, {Ilya Y.} and Paul Schedl and Shidlovskii, {Yulii V.}",
note = "Funding Information: This work was supported by the National Institutes of Health [5R01GM110015];National Institutes of Health [R35GM126975];Russian Foundation for Basic Research [16-34-60214]; Funding Information: This work was supported by the National Institutes of Health [5R01GM110015];National Institutes of Health [R35GM126975];Russian Foundation for Basic Research [16-34-60214]; We are grateful to L.V. Olenina and A.A. Kotov for their help with staining of the testes, M. Kurshakova for providing plasmid for Paip2 expression, Matthias Hentze (EMBL Heidelberg) for anti-PABP antibodies, and N.A. Gorgolyuk for his help in preparing the manuscript. This study was performed using the infrastructure of the Centre for Collective Use ?Biology of the Living Cell and Drug Biomedical Nanotransporters? of the Institute of Gene Biology, Russian Academy of Sciences. Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 Informa UK Limited, trading as Taylor & Francis Group.",
year = "2018",
month = jul,
day = "18",
doi = "10.1080/15384101.2018.1496738",
language = "English (US)",
volume = "17",
pages = "1708--1720",
journal = "Cell Cycle",
issn = "1538-4101",
publisher = "Landes Bioscience",
number = "14",
}