TY - GEN
T1 - Paclitaxel conjugate block copolymer nanoparticle formation by flash NanoPrecipitation
AU - Prud'homme, R.
AU - Saad, W.
AU - Mayer, L.
PY - 2006
Y1 - 2006
N2 - Block copolymer drug nanoparticles have been explored for their potential in solubilizing hydrophobic drugs, reducing drug toxicity, and extending drug circulation times in vivo. Key factors in such applications involve the control of stability and nanoparticle size. Flash NanoPrecipitation, which was introduced recently, is an easily scalable technique that provides high solute loading, and controlled size nanoparticles using amphiphilic diblock copolymer stabilization. Using this technology, the anticancer drug paclitaxel conjugated to vitamin E succinate was formulated into stable and controlled size nanoparticles. Conjugation of the drug to vitamin E succinate to form a paclitaxel conjugate prior to mixing by Flash Nanoprecipitation reduces its solubility, and allows for the drug release rate to be controlled through the linker chemistry used to conjugate the drug to the nanoparticle.
AB - Block copolymer drug nanoparticles have been explored for their potential in solubilizing hydrophobic drugs, reducing drug toxicity, and extending drug circulation times in vivo. Key factors in such applications involve the control of stability and nanoparticle size. Flash NanoPrecipitation, which was introduced recently, is an easily scalable technique that provides high solute loading, and controlled size nanoparticles using amphiphilic diblock copolymer stabilization. Using this technology, the anticancer drug paclitaxel conjugated to vitamin E succinate was formulated into stable and controlled size nanoparticles. Conjugation of the drug to vitamin E succinate to form a paclitaxel conjugate prior to mixing by Flash Nanoprecipitation reduces its solubility, and allows for the drug release rate to be controlled through the linker chemistry used to conjugate the drug to the nanoparticle.
KW - Diblock copolymer
KW - Nanoparticle
KW - Paclitaxel
UR - http://www.scopus.com/inward/record.url?scp=33845206600&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845206600&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:33845206600
SN - 0976798573
SN - 9780976798576
T3 - 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
SP - 824
EP - 826
BT - 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
T2 - 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Y2 - 7 May 2006 through 11 May 2006
ER -