Oxy-nitroso shielding burst model of cold atmospheric plasma therapeutics

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94 Scopus citations

Abstract

It is postulated that cold atmospheric plasma (CAP) can trigger a therapeutic shielding response in tissue by creating a time- and space-localized, burst-like form of oxy-nitrosative stress on near-surface exposed cells through the flux of plasma-generated reactive oxygen and nitrogen species (RONS). RONS-exposed surface layers of cells communicate to the deeper levels of tissue via a form of the 'bystander effect,' similar to responses to other forms of cell stress. In this proposed model of CAP therapeutics, the plasma stimulates a cellular survival mechanism through which aerobic organisms shield themselves from infection and other challenges.

Original languageEnglish (US)
Pages (from-to)38-49
Number of pages12
JournalClinical Plasma Medicine
Volume2
Issue number2
DOIs
StatePublished - Dec 1 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Dermatology

Keywords

  • Bystander effect
  • Cold atmospheric plasma
  • Hormesis
  • Plasma medicine
  • Reactive oxygen and nitrogen species

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