Oxy-nitroso shielding burst model of cold atmospheric plasma therapeutics

Research output: Contribution to journalReview articlepeer-review

94 Scopus citations


It is postulated that cold atmospheric plasma (CAP) can trigger a therapeutic shielding response in tissue by creating a time- and space-localized, burst-like form of oxy-nitrosative stress on near-surface exposed cells through the flux of plasma-generated reactive oxygen and nitrogen species (RONS). RONS-exposed surface layers of cells communicate to the deeper levels of tissue via a form of the 'bystander effect,' similar to responses to other forms of cell stress. In this proposed model of CAP therapeutics, the plasma stimulates a cellular survival mechanism through which aerobic organisms shield themselves from infection and other challenges.

Original languageEnglish (US)
Pages (from-to)38-49
Number of pages12
JournalClinical Plasma Medicine
Issue number2
StatePublished - Dec 1 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Dermatology


  • Bystander effect
  • Cold atmospheric plasma
  • Hormesis
  • Plasma medicine
  • Reactive oxygen and nitrogen species


Dive into the research topics of 'Oxy-nitroso shielding burst model of cold atmospheric plasma therapeutics'. Together they form a unique fingerprint.

Cite this