TY - CHAP
T1 - Overview of Scheduling Methods for Pharmaceutical Production
AU - Misra, Shamik
AU - Maravelias, Christos T.
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.
PY - 2022
Y1 - 2022
N2 - Pharmaceutical industries generally employ multistage production facilities with multiple shared resources to produce several low-volume products, and efficient scheduling frameworks can greatly aid in responding to demand fluctuations while utilizing the capital-intensive assets efficiently. In this chapter, we present an overview of the production scheduling models applicable to single-unit to multistage production environments. We discuss the general concepts and challenges regarding the implementation of the scheduling methods in batch pharmaceutical manufacturing and introduce mathematical programming models that can incorporate additional complexities related to changeover cost, time, and shared resources. Finally, we demonstrate the efficacy of the models discussed in this chapter through multiple case studies.
AB - Pharmaceutical industries generally employ multistage production facilities with multiple shared resources to produce several low-volume products, and efficient scheduling frameworks can greatly aid in responding to demand fluctuations while utilizing the capital-intensive assets efficiently. In this chapter, we present an overview of the production scheduling models applicable to single-unit to multistage production environments. We discuss the general concepts and challenges regarding the implementation of the scheduling methods in batch pharmaceutical manufacturing and introduce mathematical programming models that can incorporate additional complexities related to changeover cost, time, and shared resources. Finally, we demonstrate the efficacy of the models discussed in this chapter through multiple case studies.
KW - Mixed-integer programming
KW - Optimization
KW - Production scheduling
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U2 - 10.1007/978-3-030-90924-6_13
DO - 10.1007/978-3-030-90924-6_13
M3 - Chapter
AN - SCOPUS:85128044393
T3 - Springer Optimization and Its Applications
SP - 355
EP - 371
BT - Springer Optimization and Its Applications
PB - Springer
ER -