Outstanding questions in developmental ERK signaling

Aleena L. Patel, Stanislav Y. Shvartsman

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

The extracellular signal-regulated kinase (ERK) pathway leads to activation of the effector molecule ERK which controls downstream responses by phosphorylating a variety of substrates including transcription factors. Crucial insights into the regulation and function of this pathway came from studying embryos in which specific phenotypes arise fromaberrant ERK activation. Despite decades of research several important questions remain to be addressed for deeper understanding of this highly conserved signaling system and its function. Answering these questions will require quantifying the first steps of pathway activation elucidating the mechanisms of transcriptional interpretation and measuring the quantitative limits of ERK signaling within which the system must operate to avoid developmental defects.

Original languageEnglish (US)
Article numberdev143818
JournalDevelopment (Cambridge)
Volume145
Issue number14
DOIs
StatePublished - Jul 15 2018

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology

Keywords

  • Inductive ERK signaling
  • Quantitative parameters
  • Regulatory networks
  • Transcriptional interpretation

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