Outer membrane protein insertion by the β-barrel assembly machine

Dante P. Ricci, Thomas J. Silhavy

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Like all outer membrane (OM) constituents, integral OM β-barrel proteins in Gram-negative bacteria are synthesized in the cytoplasm and trafficked to the OM, where they are locally assembled into the growing OM by the ubiquitous β-barrel assembly machine (Bam). While the identities and structures of all essential and accessory Bam components have been determined, the basic mechanism of Bam-assisted OM protein integration remains elusive. Here we review mechanistic analyses of OM β-barrel protein folding and Bam dynamics and summarize recent insights that inform a general model for OM protein recognition and assembly by the Bam complex.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalEcoSal Plus
Volume8
Issue number2
DOIs
StatePublished - 2019

All Science Journal Classification (ASJC) codes

  • Microbiology

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