Origins of reduction in efficiency in microfluidic particle separation

W. Lee, H. Amini, Howard A. Stone, D. Di Carlo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Microfluidic particle separation often gets degraded by defocusing of particles at high concentration due to hydrodynamic particle-particle interactions. We theoretically and experimentally studied the origins of these interactions; the reversing wake reflected from nearby channel walls is found to be the dominant interaction. In addition we present a unique mechanism for the dynamic self-assembly particles in finite-Reynolds number channel flow. Inertial lift forces and a parabolic flow field act together to stabilize interparticle spacings that otherwise would diverge to infinity due to viscous wakes.

Original languageEnglish (US)
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages381-383
Number of pages3
StatePublished - Dec 1 2010
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: Oct 3 2010Oct 7 2010

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume1

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/3/1010/7/10

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

Keywords

  • Dynamic self-assembly
  • Hydrodynamic interaction
  • Inertial microfluidics
  • Particle separation

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  • Cite this

    Lee, W., Amini, H., Stone, H. A., & Di Carlo, D. (2010). Origins of reduction in efficiency in microfluidic particle separation. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 381-383). (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 1).