@article{99e1b389e82149cbb4d780aa16a65e2a,
title = "Oriented collagen fibers direct tumor cell intravasation",
abstract = "In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).",
keywords = "Cancer, Collagen, Intravasation, Microenvironment, Oriented invasion",
author = "Weijing Han and Shaohua Chen and Wei Yuan and Qihui Fan and Jianxiang Tian and Xiaochen Wang and Longqing Chen and Xixiang Zhang and Weili Wei and Ruchuan Liu and Junle Qu and Yang Jiao and Austin, {Robert H.} and Liyu Liu",
note = "Funding Information: We thank our referees for provocative questions that greatly improved the paper. This work was supported by State Key Development Program for Basic Research of China Grant 2013CB837200, National Natural Science Foundation of China Grants 11474345 and 11274200, Beijing Natural Science Foundation Grant 7154221, National Cancer Institute Grant U54CA143803, and Arizona State University startup funds. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health. Publisher Copyright: {\textcopyright} 2016, National Academy of Sciences. All rights reserved.",
year = "2016",
month = oct,
day = "4",
doi = "10.1073/pnas.1610347113",
language = "English (US)",
volume = "113",
pages = "11208--11213",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "40",
}