Organotropism of breast cancer metastasis

Xin Lu, Yibin Kang

Research output: Contribution to journalArticle

141 Scopus citations

Abstract

Breast cancer causes mortality by metastasizing to a variety of vital organs, such as bone, lung, brain and liver. Effective therapeutic intervention of this deadly process relies on a better mechanistic understanding of metastasis organotropism. Recent studies have confirmed earlier speculations that metastasis is a non-random process and is dependent on intricate tumor-stroma interactions at the target organ. Both the intrinsic properties of breast cancer cells and the host organ microenvironment are important in determining the efficiency of organ-specific metastasis. Advances in animal modeling, in vivo imaging and functional genomics have accelerated the discovery of important molecular mediators of organ-specific metastasis. A conceptual framework of breast cancer organotropism is emerging and will be instrumental in guiding future efforts in this exciting research field.

Original languageEnglish (US)
Pages (from-to)153-162
Number of pages10
JournalJournal of Mammary Gland Biology and Neoplasia
Volume12
Issue number2-3
DOIs
StatePublished - Sep 1 2007

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • Bone metastasis
  • Breast cancer
  • Cancer stem cell
  • Lung metastasis
  • Metastasis
  • Metastasis niche
  • Organotropism
  • Tissue-specific metastasis

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