Optogenetics and biosensors set the stage for metabolic cybergenetics

César Carrasco-López, Sergio A. García-Echauri, Therese Kichuk, José L. Avalos

Research output: Contribution to journalReview article

Abstract

Cybergenetic systems use computer interfaces to enable feed-back controls over biological processes in real time. The complex and dynamic nature of cellular metabolism makes cybergenetics attractive for controlling engineered metabolic pathways in microbial fermentations. Cybergenetics would not only create new avenues of research into cellular metabolism, it would also enable unprecedented strategies for pathway optimization and bioreactor operation and automation. Implementation of metabolic cybergenetics, however, will require new capabilities from actuators, biosensors, and control algorithms. The recent application of optogenetics in metabolic engineering, the expanding role of genetically encoded biosensors in strain development, and continued progress in control algorithms for biological processes suggest that this technology will become available in the not so distant future.

Original languageEnglish (US)
Pages (from-to)296-309
Number of pages14
JournalCurrent Opinion in Biotechnology
Volume65
DOIs
StatePublished - Oct 2020

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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