Optimizing the laser-pulse configuration for coherent Raman spectroscopy

Dmitry Pestov, Robert K. Murawski, Gombojav O. Ariunbold, Xi Wang, Miaochan Zhi, Alexei V. Sokolov, Vladimir A. Sautenkov, Yuri V. Rostovtsev, Arthur Dogariu, Yu Huang, Marian O. Scully

Research output: Contribution to journalArticlepeer-review

263 Scopus citations

Abstract

We introduce a hybrid technique that combines the robustness of frequency-resolved coherent anti-Stokes Raman scattering (CARS) with the advantages of time-resolved CARS spectroscopy. Instantaneous coherent broadband excitation of several characteristic molecular vibrations and the subsequent probing of these vibrations by an optimally shaped time-delayed narrowband laser pulse help to suppress the nonresonant background and to retrieve the species-specific signal. We used this technique for coherent Raman spectroscopy of sodium dipicolinate powder, which is similar to calcium dipicolinate (a marker molecule for bacterial endospores, such as Bacillus subtilis and Bacillus anthracis), and we demonstrated a rapid and highly specific detection scheme that works even in the presence of multiple scattering.

Original languageEnglish (US)
Pages (from-to)265-268
Number of pages4
JournalScience
Volume316
Issue number5822
DOIs
StatePublished - Apr 13 2007

All Science Journal Classification (ASJC) codes

  • General

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