On the implications of endogenous resistance to medications.

Ramanan Laxminarayan, Martin L. Weitzman

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Uniform treatment guidelines are often used in medicine to ensure that all physicians prescribe a safe, efficacious, and cost-effective drug in treating a medical condition. The main message of this paper is that a policy of uniform treatment based on the standard cost-effectiveness criterion may be inappropriate when drug resistance is endogenous, and selection pressure imposed by the use of any single drug (antibiotic, antiviral, or antimalarial) leads sooner or later to the evolution of resistance (by bacteria, viruses, or parasites) to that drug. The paper shows that a mixed treatment policy of multiple drug use is generally desirable, and characterizes analytically the conditions under which it is optimal.

Original languageEnglish (US)
Pages (from-to)709-718
Number of pages10
JournalJournal of Health Economics
Issue number4
StatePublished - Jul 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Health Policy
  • Public Health, Environmental and Occupational Health


Dive into the research topics of 'On the implications of endogenous resistance to medications.'. Together they form a unique fingerprint.

Cite this