### Abstract

We study the tandem duplication distance between binary sequences and their roots. This distance is motivated by genomic tandem duplication mutations and counts the smallest number of tandem duplication events that are required to take one sequence to another. We consider both exact and approximate tandem duplications, the latter leading to a combined duplication/Hamming distance. The paper focuses on the maximum value of the duplication distance to the root. For exact duplication, denoting the maximum distance to the root of a sequence of length n by f(n), we prove that f(n) = Θ(n). For the case of approximate duplication, where a β-fraction of symbols may be duplicated incorrectly, we show using the Plotkin bound that the maximum distance has a sharp transition from linear to logarithmic in n at β = 1/2.

Original language | English (US) |
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Title of host publication | Proceedings - ISIT 2016; 2016 IEEE International Symposium on Information Theory |

Publisher | Institute of Electrical and Electronics Engineers Inc. |

Pages | 260-264 |

Number of pages | 5 |

ISBN (Electronic) | 9781509018062 |

DOIs | |

State | Published - Aug 10 2016 |

Externally published | Yes |

Event | 2016 IEEE International Symposium on Information Theory, ISIT 2016 - Barcelona, Spain Duration: Jul 10 2016 → Jul 15 2016 |

### Publication series

Name | IEEE International Symposium on Information Theory - Proceedings |
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Volume | 2016-August |

ISSN (Print) | 2157-8095 |

### Other

Other | 2016 IEEE International Symposium on Information Theory, ISIT 2016 |
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Country | Spain |

City | Barcelona |

Period | 7/10/16 → 7/15/16 |

### All Science Journal Classification (ASJC) codes

- Theoretical Computer Science
- Information Systems
- Modeling and Simulation
- Applied Mathematics

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## Cite this

*Proceedings - ISIT 2016; 2016 IEEE International Symposium on Information Theory*(pp. 260-264). [7541301] (IEEE International Symposium on Information Theory - Proceedings; Vol. 2016-August). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ISIT.2016.7541301