Olfactory inputs to hypothalamic neurons controlling reproduction and fertility

Hayan Yoon, L. W. Enquist, Catherine Dulac

Research output: Contribution to journalArticle

296 Scopus citations

Abstract

In order to gain insight into sensory processing modulating reproductive behavioral and endocrine changes, we have aimed at identifying afferent pathways to neurons synthesizing luteinizing hormone-releasing hormone (LHRH, also known as gonadotropin-releasing hormone [GnRH]), a key neurohormone of reproduction. Injection of conditional pseudorabies virus into the brain of an LHRH::CRE mouse line led to the identification of neuronal networks connected to LHRH neurons. Remarkably, and in contrast to established notions on the nature of LHRH neuronal inputs, our data identify major olfactory projection pathways originating from a discrete population of olfactory sensory neurons but fail to document any synaptic connectivity with the vomeronasal system. Accordingly, chemosensory modulation of LHRH neuronal activity and mating behavior are dramatically impaired in absence of olfactory function, while they appear unaffected in mouse mutants lacking vomeronasal signaling. Further visualization of afferents to LHRH neurons across the brain offers a unique opportunity to uncover complex polysynaptic circuits modulating reproduction and fertility.

Original languageEnglish (US)
Pages (from-to)669-682
Number of pages14
JournalCell
Volume123
Issue number4
DOIs
StatePublished - Nov 18 2005

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Olfactory inputs to hypothalamic neurons controlling reproduction and fertility'. Together they form a unique fingerprint.

  • Cite this