Of extracellular matrix, scaffolds, and signaling: Tissue architecture regulates development, homeostasis, and cancer

Celeste M. Nelson, Mina J. Bissell

Research output: Chapter in Book/Report/Conference proceedingChapter

753 Scopus citations

Abstract

The microenvironment influences gene expression so that the behavior of a cell is largely determined by its interactions with the extracellular matrix, neighboring cells, and soluble local and systemic cues. We describe the essential roles of context and organ structure in directing mammary gland development and differentiated function and in determining the response to oncogenic insults, including mutations. We expand on the concept of "dynamic reciprocity" to present an integrated view of development, cancer, and aging and posit that genes are like the keys on a piano: Although they are essential, it is the context that makes the music.

Original languageEnglish (US)
Title of host publicationAnnual Review of Cell and Developmental Biology
EditorsRandy Schekman, Larry Goldstein, Janet Rossant
Pages287-309
Number of pages23
DOIs
StatePublished - 2006

Publication series

NameAnnual Review of Cell and Developmental Biology
Volume22
ISSN (Print)1081-0706

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

Keywords

  • Differentiation
  • Mammary gland
  • Microenvironment
  • Morphogenesis
  • Stromal-epithelial interactions
  • Tissue context

Fingerprint Dive into the research topics of 'Of extracellular matrix, scaffolds, and signaling: Tissue architecture regulates development, homeostasis, and cancer'. Together they form a unique fingerprint.

Cite this