Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

Alison E. Ringel; Jefte M. Drijvers; Gregory J. Baker; Alessia Catozzi; Juan C. García-Cañaveras; Brandon M. Gassaway; Brian C. Miller; Vikram R. Juneja; Thao H. Nguyen; Shakchhi Joshi; Cong Hui Yao; Haejin Yoon; Peter T. Sage; Martin W. LaFleur; Justin D. Trombley; Connor A. Jacobson; Zoltan Maliga; Steven P. Gygi; Peter K. Sorger; Joshua D. Rabinowitz; Arlene H. Sharpe; Marcia C. Haigis

doi:10.1016/j.cell.2020.11.009

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

Alison E. Ringel
, Jefte M. Drijvers
, Gregory J. Baker
, Alessia Catozzi
, Juan C. García-Cañaveras
, Brandon M. Gassaway
, Brian C. Miller
, Vikram R. Juneja
, Thao H. Nguyen
, Shakchhi Joshi
, Cong Hui Yao
, Haejin Yoon
, Peter T. Sage
, Martin W. LaFleur
, Justin D. Trombley
, Connor A. Jacobson
, Zoltan Maliga
, Steven P. Gygi
, Peter K. Sorger
, Joshua D. Rabinowitz

Arlene H. Sharpe, Marcia C. Haigis

Research output: Contribution to journal › Article › peer-review

565 Scopus citations

Abstract

High-fat diet compromises anti-tumor immunity by interfering with metabolism in the tumor microenvironment.

Original language	English (US)
Pages (from-to)	1848-1866.e26
Journal	Cell
Volume	183
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2020.11.009
State	Published - Dec 23 2020

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

Keywords

CD8+ T cells
anti-tumor immunity
colorectal cancer
fat oxidation
metabolism
obesity
tumor microenvironment

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10.1016/j.cell.2020.11.009

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Ringel, A. E., Drijvers, J. M., Baker, G. J., Catozzi, A., García-Cañaveras, J. C., Gassaway, B. M., Miller, B. C., Juneja, V. R., Nguyen, T. H., Joshi, S., Yao, C. H., Yoon, H., Sage, P. T., LaFleur, M. W., Trombley, J. D., Jacobson, C. A., Maliga, Z., Gygi, S. P., Sorger, P. K., ... Haigis, M. C. (2020). Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity. Cell, 183(7), 1848-1866.e26. https://doi.org/10.1016/j.cell.2020.11.009

@article{f59881aa54c940a18cd8ba5b1ec2c8aa,

title = "Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity",

abstract = "High-fat diet compromises anti-tumor immunity by interfering with metabolism in the tumor microenvironment.",

keywords = "CD8+ T cells, anti-tumor immunity, colorectal cancer, fat oxidation, metabolism, obesity, tumor microenvironment",

author = "Ringel, \{Alison E.\} and Drijvers, \{Jefte M.\} and Baker, \{Gregory J.\} and Alessia Catozzi and Garc{\'i}a-Ca{\~n}averas, \{Juan C.\} and Gassaway, \{Brandon M.\} and Miller, \{Brian C.\} and Juneja, \{Vikram R.\} and Nguyen, \{Thao H.\} and Shakchhi Joshi and Yao, \{Cong Hui\} and Haejin Yoon and Sage, \{Peter T.\} and LaFleur, \{Martin W.\} and Trombley, \{Justin D.\} and Jacobson, \{Connor A.\} and Zoltan Maliga and Gygi, \{Steven P.\} and Sorger, \{Peter K.\} and Rabinowitz, \{Joshua D.\} and Sharpe, \{Arlene H.\} and Haigis, \{Marcia C.\}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = dec,

day = "23",

doi = "10.1016/j.cell.2020.11.009",

language = "English (US)",

volume = "183",

pages = "1848--1866.e26",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "7",

}

Ringel, AE, Drijvers, JM, Baker, GJ, Catozzi, A, García-Cañaveras, JC, Gassaway, BM, Miller, BC, Juneja, VR, Nguyen, TH, Joshi, S, Yao, CH, Yoon, H, Sage, PT, LaFleur, MW, Trombley, JD, Jacobson, CA, Maliga, Z, Gygi, SP, Sorger, PK, Rabinowitz, JD, Sharpe, AH & Haigis, MC 2020, 'Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity', Cell, vol. 183, no. 7, pp. 1848-1866.e26. https://doi.org/10.1016/j.cell.2020.11.009

TY - JOUR

T1 - Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

AU - Ringel, Alison E.

AU - Drijvers, Jefte M.

AU - Baker, Gregory J.

AU - Catozzi, Alessia

AU - García-Cañaveras, Juan C.

AU - Gassaway, Brandon M.

AU - Miller, Brian C.

AU - Juneja, Vikram R.

AU - Nguyen, Thao H.

AU - Joshi, Shakchhi

AU - Yao, Cong Hui

AU - Yoon, Haejin

AU - Sage, Peter T.

AU - LaFleur, Martin W.

AU - Trombley, Justin D.

AU - Jacobson, Connor A.

AU - Maliga, Zoltan

AU - Gygi, Steven P.

AU - Sorger, Peter K.

AU - Rabinowitz, Joshua D.

AU - Sharpe, Arlene H.

AU - Haigis, Marcia C.

PY - 2020/12/23

Y1 - 2020/12/23

N2 - High-fat diet compromises anti-tumor immunity by interfering with metabolism in the tumor microenvironment.

AB - High-fat diet compromises anti-tumor immunity by interfering with metabolism in the tumor microenvironment.

KW - CD8+ T cells

KW - anti-tumor immunity

KW - colorectal cancer

KW - fat oxidation

KW - metabolism

KW - obesity

KW - tumor microenvironment

UR - https://www.scopus.com/pages/publications/85097881150

UR - https://www.scopus.com/pages/publications/85097881150#tab=citedBy

U2 - 10.1016/j.cell.2020.11.009

DO - 10.1016/j.cell.2020.11.009

M3 - Article

C2 - 33301708

AN - SCOPUS:85097881150

SN - 0092-8674

VL - 183

SP - 1848-1866.e26

JO - Cell

JF - Cell

IS - 7

ER -

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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