Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

Alison E. Ringel; Jefte M. Drijvers; Gregory J. Baker; Alessia Catozzi; Juan C. García-Cañaveras; Brandon M. Gassaway; Brian C. Miller; Vikram R. Juneja; Thao H. Nguyen; Shakchhi Joshi; Cong Hui Yao; Haejin Yoon; Peter T. Sage; Martin W. LaFleur; Justin D. Trombley; Connor A. Jacobson; Zoltan Maliga; Steven P. Gygi; Peter K. Sorger; Joshua D. Rabinowitz; Arlene H. Sharpe; Marcia C. Haigis

doi:10.1016/j.cell.2020.11.009

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

Alison E. Ringel, Jefte M. Drijvers, Gregory J. Baker, Alessia Catozzi, Juan C. García-Cañaveras, Brandon M. Gassaway, Brian C. Miller, Vikram R. Juneja, Thao H. Nguyen, Shakchhi Joshi, Cong Hui Yao, Haejin Yoon, Peter T. Sage, Martin W. LaFleur, Justin D. Trombley, Connor A. Jacobson, Zoltan Maliga, Steven P. Gygi, Peter K. Sorger, Joshua D. RabinowitzArlene H. Sharpe, Marcia C. Haigis

Research output: Contribution to journal › Article › peer-review

501 Scopus citations

Abstract

High-fat diet compromises anti-tumor immunity by interfering with metabolism in the tumor microenvironment.

Original language	English (US)
Pages (from-to)	1848-1866.e26
Journal	Cell
Volume	183
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2020.11.009
State	Published - Dec 23 2020

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

Keywords

CD8+ T cells
anti-tumor immunity
colorectal cancer
fat oxidation
metabolism
obesity
tumor microenvironment

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10.1016/j.cell.2020.11.009

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Ringel, A. E., Drijvers, J. M., Baker, G. J., Catozzi, A., García-Cañaveras, J. C., Gassaway, B. M., Miller, B. C., Juneja, V. R., Nguyen, T. H., Joshi, S., Yao, C. H., Yoon, H., Sage, P. T., LaFleur, M. W., Trombley, J. D., Jacobson, C. A., Maliga, Z., Gygi, S. P., Sorger, P. K., ... Haigis, M. C. (2020). Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity. Cell, 183(7), 1848-1866.e26. https://doi.org/10.1016/j.cell.2020.11.009

@article{f59881aa54c940a18cd8ba5b1ec2c8aa,

title = "Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity",

abstract = "High-fat diet compromises anti-tumor immunity by interfering with metabolism in the tumor microenvironment.",

keywords = "CD8+ T cells, anti-tumor immunity, colorectal cancer, fat oxidation, metabolism, obesity, tumor microenvironment",

author = "Ringel, \{Alison E.\} and Drijvers, \{Jefte M.\} and Baker, \{Gregory J.\} and Alessia Catozzi and Garc{\'i}a-Ca{\~n}averas, \{Juan C.\} and Gassaway, \{Brandon M.\} and Miller, \{Brian C.\} and Juneja, \{Vikram R.\} and Nguyen, \{Thao H.\} and Shakchhi Joshi and Yao, \{Cong Hui\} and Haejin Yoon and Sage, \{Peter T.\} and LaFleur, \{Martin W.\} and Trombley, \{Justin D.\} and Jacobson, \{Connor A.\} and Zoltan Maliga and Gygi, \{Steven P.\} and Sorger, \{Peter K.\} and Rabinowitz, \{Joshua D.\} and Sharpe, \{Arlene H.\} and Haigis, \{Marcia C.\}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = dec,

day = "23",

doi = "10.1016/j.cell.2020.11.009",

language = "English (US)",

volume = "183",

pages = "1848--1866.e26",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "7",

}

Ringel, AE, Drijvers, JM, Baker, GJ, Catozzi, A, García-Cañaveras, JC, Gassaway, BM, Miller, BC, Juneja, VR, Nguyen, TH, Joshi, S, Yao, CH, Yoon, H, Sage, PT, LaFleur, MW, Trombley, JD, Jacobson, CA, Maliga, Z, Gygi, SP, Sorger, PK, Rabinowitz, JD, Sharpe, AH & Haigis, MC 2020, 'Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity', Cell, vol. 183, no. 7, pp. 1848-1866.e26. https://doi.org/10.1016/j.cell.2020.11.009

TY - JOUR

T1 - Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

AU - Ringel, Alison E.

AU - Drijvers, Jefte M.

AU - Baker, Gregory J.

AU - Catozzi, Alessia

AU - García-Cañaveras, Juan C.

AU - Gassaway, Brandon M.

AU - Miller, Brian C.

AU - Juneja, Vikram R.

AU - Nguyen, Thao H.

AU - Joshi, Shakchhi

AU - Yao, Cong Hui

AU - Yoon, Haejin

AU - Sage, Peter T.

AU - LaFleur, Martin W.

AU - Trombley, Justin D.

AU - Jacobson, Connor A.

AU - Maliga, Zoltan

AU - Gygi, Steven P.

AU - Sorger, Peter K.

AU - Rabinowitz, Joshua D.

AU - Sharpe, Arlene H.

AU - Haigis, Marcia C.

PY - 2020/12/23

Y1 - 2020/12/23

N2 - High-fat diet compromises anti-tumor immunity by interfering with metabolism in the tumor microenvironment.

AB - High-fat diet compromises anti-tumor immunity by interfering with metabolism in the tumor microenvironment.

KW - CD8+ T cells

KW - anti-tumor immunity

KW - colorectal cancer

KW - fat oxidation

KW - metabolism

KW - obesity

KW - tumor microenvironment

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DO - 10.1016/j.cell.2020.11.009

M3 - Article

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AN - SCOPUS:85097881150

SN - 0092-8674

VL - 183

SP - 1848-1866.e26

JO - Cell

JF - Cell

IS - 7

ER -

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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