Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

Alison E. Ringel, Jefte M. Drijvers, Gregory J. Baker, Alessia Catozzi, Juan C. García-Cañaveras, Brandon M. Gassaway, Brian C. Miller, Vikram R. Juneja, Thao H. Nguyen, Shakchhi Joshi, Cong Hui Yao, Haejin Yoon, Peter T. Sage, Martin W. LaFleur, Justin D. Trombley, Connor A. Jacobson, Zoltan Maliga, Steven P. Gygi, Peter K. Sorger, Joshua D. RabinowitzArlene H. Sharpe, Marcia C. Haigis

Research output: Contribution to journalArticlepeer-review

Abstract

High-fat diet compromises anti-tumor immunity by interfering with metabolism in the tumor microenvironment.

Original languageEnglish (US)
Pages (from-to)1848-1866.e26
JournalCell
Volume183
Issue number7
DOIs
StatePublished - Dec 23 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Keywords

  • CD8+ T cells
  • anti-tumor immunity
  • colorectal cancer
  • fat oxidation
  • metabolism
  • obesity
  • tumor microenvironment

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