Abstract
High-fat diet compromises anti-tumor immunity by interfering with metabolism in the tumor microenvironment.
Original language | English (US) |
---|---|
Pages (from-to) | 1848-1866.e26 |
Journal | Cell |
Volume | 183 |
Issue number | 7 |
DOIs | |
State | Published - Dec 23 2020 |
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
Keywords
- CD8+ T cells
- anti-tumor immunity
- colorectal cancer
- fat oxidation
- metabolism
- obesity
- tumor microenvironment
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In: Cell, Vol. 183, No. 7, 23.12.2020, p. 1848-1866.e26.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity
AU - Ringel, Alison E.
AU - Drijvers, Jefte M.
AU - Baker, Gregory J.
AU - Catozzi, Alessia
AU - García-Cañaveras, Juan C.
AU - Gassaway, Brandon M.
AU - Miller, Brian C.
AU - Juneja, Vikram R.
AU - Nguyen, Thao H.
AU - Joshi, Shakchhi
AU - Yao, Cong Hui
AU - Yoon, Haejin
AU - Sage, Peter T.
AU - LaFleur, Martin W.
AU - Trombley, Justin D.
AU - Jacobson, Connor A.
AU - Maliga, Zoltan
AU - Gygi, Steven P.
AU - Sorger, Peter K.
AU - Rabinowitz, Joshua D.
AU - Sharpe, Arlene H.
AU - Haigis, Marcia C.
N1 - Funding Information: We are grateful for resources provided by the “MicRoN core at Harvard Medical School” and “HMS Immunology Flow Cytometry Core Facility.” This study was supported by grants from the Ludwig Center at Harvard Medical School (United States; to M.C.H., A.H.S., and P.K.S), NCI (National Cancer Institute, United States; U54-CA225088 to M.C.H., A.H.S., and P.K.S. and R01CA213062 to M.C.H.), the Evergrande Center for Immunologic Disease (to A.H.S.), the Glenn Foundation for Medical Research (United States; to M.C.H.), and NIH ( National Institute of Diabetes and Digestive and Kidney Diseases, United States; R01DK103295 to M.C.H. and P01 AI56299 to A.H.S). A.E.R was supported by postdoctoral fellowships from the American Cancer Society (United States; 130373-PF-17-132-01-CCG ) and Cell Biology Education and Fellowship Fund (United States; Harvard Medical School) . J.M.D. was supported by a predoctoral F31 NIH fellowship (National Institutes of Health, United States; 5F31CA224601 ). M.W.L. was supported by a predoctoral T32 NIH fellowship (National Institutes of Health, United States; T32CA207021 ). The VUMC Hormone Assay & Analytical Services and Lipid Cores are supported by NIH (National Institute of Diabetes and Digestive and Kidney Diseases, United States; DK059637 to MMPC and DK020593 to DRTC). Funding Information: We are grateful for resources provided by the ?MicRoN core at Harvard Medical School? and ?HMS Immunology Flow Cytometry Core Facility.? This study was supported by grants from the Ludwig Center at Harvard Medical School (United States; to M.C.H. A.H.S. and P.K.S), NCI (National Cancer Institute, United States; U54-CA225088 to M.C.H. A.H.S. and P.K.S. and R01CA213062 to M.C.H.), the Evergrande Center for Immunologic Disease (to A.H.S.), the Glenn Foundation for Medical Research (United States; to M.C.H.), and NIH (National Institute of Diabetes and Digestive and Kidney Diseases, United States; R01DK103295 to M.C.H. and P01 AI56299 to A.H.S). A.E.R was supported by postdoctoral fellowships from the American Cancer Society (United States; 130373-PF-17-132-01-CCG) and Cell Biology Education and Fellowship Fund (United States; Harvard Medical School). J.M.D. was supported by a predoctoral F31 NIH fellowship (National Institutes of Health, United States; 5F31CA224601). M.W.L. was supported by a predoctoral T32 NIH fellowship (National Institutes of Health, United States; T32CA207021). The VUMC Hormone Assay & Analytical Services and Lipid Cores are supported by NIH (National Institute of Diabetes and Digestive and Kidney Diseases, United States; DK059637 to MMPC and DK020593 to DRTC). Conceptualization, A.E.R. J.M.D. M.C.H. and A.H.S.; Software, G.J.B. A.E.R. and B.C.M.; Formal Analysis, A.E.R. J.M.D. and G.J.B.; Investigation, A.E.R. J.M.D. G.J.B. A.C. J.C.G.-C. B.M.G. B.C.M. V.R.J. T.H.N. S.J. C.-H.Y. H.Y. P.T.S. M.W.L. J.D.T. C.A.J. and Z.M.; Writing ? Original Draft, A.E.R. and J.M.D.; Writing ? Review & Editing, A.E.R. J.M.D. M.C.H. and A.H.S.; Visualization, A.E.R. and J.M.D.; Supervision, M.C.H. A.H.S. S.P.G. P.K.S. and J.D.R.; Funding Acquisition, M.C.H. and A.H.S. A.H.S. has patents/pending royalties on intellectual property on the PD-1 pathway from Roche and Novartis. A.H.S. is on advisory boards for Surface Oncology, Elstar, SQZ Biotechnologies, Selecta, Elpiscience, and Monopteros and has research funding from Novartis, Roche, Ipsen, Quark, and Merck. M.C.H. has patents pending on the PHD3 pathway, is on the scientific advisory board for Pori Therapeutics, and has research funding from Roche. J.M.D. has consulted for ElevateBio and Third Rock Ventures. The remaining authors declare no competing interests. Funding Information: A.H.S. has patents/pending royalties on intellectual property on the PD-1 pathway from Roche and Novartis. A.H.S. is on advisory boards for Surface Oncology, Elstar, SQZ Biotechnologies, Selecta, Elpiscience, and Monopteros and has research funding from Novartis, Roche, Ipsen, Quark, and Merck. M.C.H. has patents pending on the PHD3 pathway, is on the scientific advisory board for Pori Therapeutics, and has research funding from Roche. J.M.D. has consulted for ElevateBio and Third Rock Ventures. The remaining authors declare no competing interests. Publisher Copyright: © 2020
PY - 2020/12/23
Y1 - 2020/12/23
N2 - High-fat diet compromises anti-tumor immunity by interfering with metabolism in the tumor microenvironment.
AB - High-fat diet compromises anti-tumor immunity by interfering with metabolism in the tumor microenvironment.
KW - CD8+ T cells
KW - anti-tumor immunity
KW - colorectal cancer
KW - fat oxidation
KW - metabolism
KW - obesity
KW - tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85097881150&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85097881150&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2020.11.009
DO - 10.1016/j.cell.2020.11.009
M3 - Article
C2 - 33301708
AN - SCOPUS:85097881150
SN - 0092-8674
VL - 183
SP - 1848-1866.e26
JO - Cell
JF - Cell
IS - 7
ER -