The present work combines numerical and experimental efforts together to investigate the effect of low temperature, nano-second pulsed plasma discharges on the oxidation of C2H4/O2/Ar mixtures at 60 Torr pressure. The non-equilibrium plasma discharge is modeled by a two-temperature framework with detailed chemistry-plasma mechanism. The model shows that 75%~77% of input pulse energy was consumed in electron impact dissociation, excitation and ionization reactions, which efficiently produces significant amount of important radical species, fuel fragments and several excited species. The trends of numerical and experimental results agree well. The results from 1D model are compared with 0D model and it show that 1D model in general agrees better with experiments than 0D model. The modeling results reveal that reactions between O(1D) and hydrocarbons are importantly affecting the formation of C2H6, CH2CO, CH2O, CO, CO2, H2O2, H2O, O2(α1Δg) and O2(b1Σ+g). Due to the persistent relatively high level of O2(α1Δg) and O2(b1Σ+g), C2H2 converts into HCO directly without the need of going through the intermediate species of HCCO, CH2* and CH2 in the case without plasma. Owing to the long lifetime of O2(α1Δg), this effect can last to 3.1 sec after the finish of all 150 pulses.