Novel stimuli evoke excess activity in the mouse primary visual cortex

Jan Homann, Sue Ann Koay, Kevin S. Chen, David W. Tank, Michael J. Berry

Research output: Contribution to journalArticlepeer-review

Abstract

To explore how neural circuits represent novel versus familiar inputs, we presented mice with repeated sets of images with novel images sparsely substituted. Using two-photon calcium imaging to record from layer 2/3 neurons in the mouse primary visual cortex, we found that novel images evoked excess activity in the majority of neurons. This novelty response rapidly emerged, arising with a time constant of 2.6 ± 0.9 s. When a new image set was repeatedly presented, a majority of neurons had similarly elevated activity for the first few presentations, which decayed to steady state with a time constant of 1.4 ± 0.4 s. When we increased the number of images in the set, the novelty response's amplitude decreased, defining a capacity to store ∼15 familiar images under our conditions. These results could be explained quantitatively using an adaptive subunit model in which presynaptic neurons have individual tuning and gain control. This result shows that local neural circuits can create different representations for novel versus familiar inputs using generic, widely available mechanisms.

Original languageEnglish (US)
JournalProceedings of the National Academy of Sciences of the United States of America
Volume119
Issue number5
DOIs
StatePublished - Feb 1 2022

All Science Journal Classification (ASJC) codes

  • General

Keywords

  • adaptation
  • novelty response
  • predictive coding
  • primary visual cortex
  • visual system

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