Novel proteins: From fold to function

Betsy A. Smith, Michael H. Hecht

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations


The field of de novo protein design, though only two decades old, has already reached the point where designing and selecting novel proteins that are functionally active has been achieved several times. Here we review recently reported de novo functional proteins that were developed using various approaches, including rational design, computational optimization, and selection from combinatorial libraries. The functions displayed by these proteins range from metal binding to enzymatic catalysis. Some were designed for specific applications in engineering and medicine, and others provide life-sustaining functions in vivo.

Original languageEnglish (US)
Pages (from-to)421-426
Number of pages6
JournalCurrent Opinion in Chemical Biology
Issue number3
StatePublished - Jun 2011

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry


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