Novel nanoplasmonic-enhanced D2PA microfluidic immunoassay with 2.8 ng/mL (66 pM) sensitivity in 100 nL sample volume and 4 minutes total assay time

Stephen Y. Chou, Ruoming Peng, Liangcheng Zhou, Qi Zhang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Here we report a new ultra-sensitive fluorescent immunoassay, well suited for point of care (POC) diagnosis, that comprises a novel ultra-sensitive plasmonic-enhanced fluorescent sensor integrated in a microfluidic system, which has demonstrated 2.8ng/mL (66 pM) limit of detection (LoD) for Protein A detection immunoassay in 100 nL-sample volume and 4 minutes total assay time. The LoD is 10,000 fold better than glass microfiuidic reference.

Original languageEnglish (US)
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages1421-1423
Number of pages3
ISBN (Print)9781632666246
StatePublished - Jan 1 2013
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: Oct 27 2013Oct 31 2013

Publication series

Name17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Volume3

Other

Other17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
CountryGermany
CityFreiburg
Period10/27/1310/31/13

All Science Journal Classification (ASJC) codes

  • Bioengineering

Keywords

  • Fast
  • Immunoassay
  • Limit of detection
  • Nanostructures
  • Plasmonics
  • Sample volume
  • Ultra-sensitive

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