Notch signalling in cancer progression and bone metastasis

N. Sethi, Y. Kang

Research output: Contribution to journalReview article

58 Scopus citations

Abstract

Classically known for its indispensible role in embryonic development, the Notch signalling pathway is gaining recognition for its regulation of adult tissue homoeostasis and aberrant activation in disease pathogenesis. The pathway has been implicated in cancer initiation and development, as well as early stages of cancer progression by regulating conserved cellular programs such as the epithelial-to-mesenchymal transition. We recently extended the role of Notch signalling to late stages of tumour progression by elucidating a stroma-dependent mechanism for the pathway in osteolytic bone metastasis. Of clinical significance, disrupting the Notch pathway and associated molecular mediators of Notch-dependent bone metastasis may provide novel therapeutic strategies to combat aggressive bone metastatic disease.

Original languageEnglish (US)
Pages (from-to)1805-1810
Number of pages6
JournalBritish Journal of Cancer
Volume105
Issue number12
DOIs
StatePublished - Dec 6 2011

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • Bone metastasis
  • Jagged1
  • Notch signalling
  • Tumour progression

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