Nosylaziridines: Activated aziridine electrophiles

Peter E. Maligres; Marjorie M. See; David Askin; Paul J. Reider

doi:10.1016/S0040-4039(97)01157-X

Nosylaziridines: Activated aziridine electrophiles

Peter E. Maligres, Marjorie M. See, David Askin, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

128 Scopus citations

Abstract

Nosylaziridines are highly reactive electrophiles towards a variety of nucleophiles yielding the corresponding SN2 adducts without competing attack on the nosyl functionality (SNAr). The resulting primary nosylamide adducts can he readily cleaved under mild conditions to provide the primary amines.

Original language	English (US)
Pages (from-to)	5253-5256
Number of pages	4
Journal	Tetrahedron Letters
Volume	38
Issue number	30
DOIs	https://doi.org/10.1016/S0040-4039(97)01157-X
State	Published - Jul 28 1997
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(97)01157-X

Cite this

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title = "Nosylaziridines: Activated aziridine electrophiles",

abstract = "Nosylaziridines are highly reactive electrophiles towards a variety of nucleophiles yielding the corresponding SN2 adducts without competing attack on the nosyl functionality (SNAr). The resulting primary nosylamide adducts can he readily cleaved under mild conditions to provide the primary amines.",

author = "Maligres, {Peter E.} and See, {Marjorie M.} and David Askin and Reider, {Paul J.}",

year = "1997",

month = jul,

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doi = "10.1016/S0040-4039(97)01157-X",

language = "English (US)",

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pages = "5253--5256",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "30",

}

TY - JOUR

T1 - Nosylaziridines

T2 - Activated aziridine electrophiles

AU - Maligres, Peter E.

AU - See, Marjorie M.

AU - Askin, David

AU - Reider, Paul J.

PY - 1997/7/28

Y1 - 1997/7/28

N2 - Nosylaziridines are highly reactive electrophiles towards a variety of nucleophiles yielding the corresponding SN2 adducts without competing attack on the nosyl functionality (SNAr). The resulting primary nosylamide adducts can he readily cleaved under mild conditions to provide the primary amines.

AB - Nosylaziridines are highly reactive electrophiles towards a variety of nucleophiles yielding the corresponding SN2 adducts without competing attack on the nosyl functionality (SNAr). The resulting primary nosylamide adducts can he readily cleaved under mild conditions to provide the primary amines.

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U2 - 10.1016/S0040-4039(97)01157-X

DO - 10.1016/S0040-4039(97)01157-X

M3 - Article

AN - SCOPUS:0030790051

SN - 0040-4039

VL - 38

SP - 5253

EP - 5256

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 30

ER -

Nosylaziridines: Activated aziridine electrophiles

Abstract

All Science Journal Classification (ASJC) codes

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