Nosylaziridines: Activated aziridine electrophiles

Peter E. Maligres, Marjorie M. See, David Askin, Paul J. Reider

Research output: Contribution to journalArticlepeer-review

123 Scopus citations

Abstract

Nosylaziridines are highly reactive electrophiles towards a variety of nucleophiles yielding the corresponding SN2 adducts without competing attack on the nosyl functionality (SNAr). The resulting primary nosylamide adducts can he readily cleaved under mild conditions to provide the primary amines.

Original languageEnglish (US)
Pages (from-to)5253-5256
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number30
DOIs
StatePublished - Jul 28 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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