@article{5679b0c5800c42fab25fb7ecb9794afe,
title = "Normal cognitive and social development require posterior cerebellar activity",
abstract = "Cognitive and social capacities require postnatal experience, yet the pathways by which experience guides development are unknown. Here we show that the normal development of motor and nonmotor capacities requires cerebellar activity. Using chemogenetic perturbation of molecular layer interneurons to attenuate cerebellar output in mice, we found that activity of posterior regions in juvenile life modulates adult expression of eyeblink conditioning (paravermal lobule VI, crus I), reversal learning (lobule VI), persistive behavior and novelty-seeking (lobule VII), and social preference (crus I/II). Perturbation in adult life altered only a subset of phenotypes. Both adult and juvenile disruption left gait metrics largely unaffected. Contributions to phenotypes increased with the amount of lobule inactivated. Using an anterograde transsynaptic tracer, we found that posterior cerebellum made strong connections with prelimbic, orbitofrontal, and anterior cingulate cortex. These findings provide anatomical substrates for the clinical observation that cerebellar injury increases the risk of autism.",
author = "Aleksandra Badura and Verpeut, {Jessica L.} and Metzger, {Julia W.} and Pereira, {Talmo D.} and Pisano, {Thomas J.} and Ben Deverett and Bakshinskaya, {Dariya E.} and Wang, {Samuel S.H.}",
note = "Funding Information: We thank Chris De Zeeuw and the laboratory of SW for support and commentary during this project, Chris De Zeeuw, Kelly Seagraves, Junuk Lee, and Lindsay Willmore for reading the manuscript, Julia Epelbaum, Zhenyu Gao, and Laura Lynch for help with experiments, and Halina Goraczniak and Lynn Enquist for HSV-H129 virus. This work was supported by Innovational Research Incentives Scheme VENI (NWO, ZonMw) (AB), the Nancy Lurie Marks Family Foundation, NIH R01 NS045193 and R01 MH115750 (SW), the New Jersey Commission on Brain Injury Research CBIR16FEL010 (JV), National Science Foundation Graduate Research Fellowship DGE-1148900 (TDP), NIH F31 NS089303 (TJP), NIH F30 MH115577 (BD), and the Rutgers Robert Wood Johnson Medical School-Princeton University M.D. - Ph.D. Program (BD and TJP). Funding Information: We thank Chris De Zeeuw and the laboratory of SW for support and commentary during this project, Chris De Zeeuw, Kelly Seagraves, Junuk Lee, and Lindsay Willmore for reading the manuscript, Julia Epelbaum, Zhenyu Gao, and Laura Lynch for help with experiments, and Halina Goraczniak and Lynn Enquist for HSV-H129 virus. This work was supported by Innovational Research Incentives Scheme VENI (NWO, ZonMw) (AB), the Nancy Lurie Marks Family Foundation, NIH R01 NS045193 and R01 MH115750 (SW), the New Jersey Commission on Brain Injury Research CBIR16FEL010 (JV), National Science Foundation Graduate Research Fellowship DGE-1148900 (TDP), NIH F31 NS089303 (TJP), NIH F30 MH115577 (BD), and the Rutgers Robert Wood Johnson Medical School-Princeton University M.D.-Ph.D. Program (BD and TJP). Nederlandse Organisatie voor Wetenschappelijk Onderzoek Innovational Research Incentives Scheme VENI (NOW, ZonMw) Aleksandra Badura Nancy Lurie Marks Family Foundation Samuel S-H Wang National Institutes of Health R01 NS045193 Samuel S-H Wang New Jersey Commission on Brain Injury Research CBIR16FEL010 Jessica L Verpeut National Science Foundation Graduate Research Fellowship DGE-1148900 Talmo D Pereira Rutgers Robert Wood Johnson Medical School-Princeton University M.D.-Ph.D. Program Thomas J Pisano Ben Deverett National Institutes of Health R01 MH115750 Samuel S-H Wang National Institutes of Health F30 MH115577 Ben Deverett National Institutes of Health F31 NS089303 Thomas J Pisano The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Publisher Copyright: {\textcopyright} Badura et al.",
year = "2018",
month = sep,
doi = "10.7554/eLife.36401",
language = "English (US)",
volume = "7",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",
}