Abstract
Mid-infrared quantum cascade laser spectroscopy is used to noninvasively predict blood glucose concentrations of three healthy human subjects in vivo. We utilize a hollow-core fiber based optical setup for light delivery and collection along with a broadly tunable quantum cascade laser to obtain spectra from human subjects and use standard chemo-metric techniques (namely partial least squares regression) for prediction analysis. Throughout a glucose concentration range of 80-160 mg/dL, we achieve clinically accurate predictions 84% of the time, on average. This work opens a new path to a noninvasive in vivo glucose sensor that would benefit the lives of hundreds of millions of diabetics worldwide.
Original language | English (US) |
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Pages (from-to) | 2397-2404 |
Number of pages | 8 |
Journal | Biomedical Optics Express |
Volume | 5 |
Issue number | 7 |
DOIs | |
State | Published - Jun 1 2014 |
All Science Journal Classification (ASJC) codes
- Biotechnology
- Atomic and Molecular Physics, and Optics