Noninvasive in vivo glucose sensing on human subjects using mid-infrared light

Sabbir Liakat, Kevin A. Bors, Laura Xu, Callie M. Woods, Jessica Doyle, Claire F. Gmachl

Research output: Contribution to journalArticlepeer-review

113 Scopus citations


Mid-infrared quantum cascade laser spectroscopy is used to noninvasively predict blood glucose concentrations of three healthy human subjects in vivo. We utilize a hollow-core fiber based optical setup for light delivery and collection along with a broadly tunable quantum cascade laser to obtain spectra from human subjects and use standard chemo-metric techniques (namely partial least squares regression) for prediction analysis. Throughout a glucose concentration range of 80-160 mg/dL, we achieve clinically accurate predictions 84% of the time, on average. This work opens a new path to a noninvasive in vivo glucose sensor that would benefit the lives of hundreds of millions of diabetics worldwide.

Original languageEnglish (US)
Pages (from-to)2397-2404
Number of pages8
JournalBiomedical Optics Express
Issue number7
StatePublished - Jun 1 2014

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics
  • Biotechnology


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