Nondisjunction rates and abnormal embryonic development in a mouse cross between heterozygotes carrying a (7, 18) Robertsonian translocation chromosome

R. J. Oakey, P. G. Matteson, S. Litwin, Shirley Marie Tilghman, R. L. Nussbaum

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Mice bearing Robertsonian translocation chromosomes frequently produce aneuploid gametes. They are therefore excellent tools for studying nondisjunction in mammals. Genotypic analysis of embryos from a mouse cross between two different strains of mice carrying a (7, 18) Robertsonian chromosome enabled us to measure the rate of nondisjunction for chromosomes 7 and 18. Embryos (429) were harvested from 76 litters of mice and the parental origin of each chromosome 7 and 18 determined. Genotyping these embryos has allowed us to conclude the following: (1) there were 96 embryos in which at least one nondisjunction event had taken place; (2) the rate of maternal nondisjunction was greater than paternal nondisjunction for the chromosomes sampled in these mice; (3) a bias against chromosome 7 and 18 nullisomic gametes was observed, reflected in a smaller than expected number of uniparental disomic embryos; (4) nondisjunction events did not seem to occur at random throughout the 76 mouse litters, but were clustered into fewer than would be expected by chance; and (5) a deficiency of paternal chromosome 18 uniparental disomic embryos was observed along with a higher than normal rate of developmental retardation at 8.5 days post coitum, raising the possibility that this chromosome has at least one imprinted gene.

Original languageEnglish (US)
Pages (from-to)667-674
Number of pages8
JournalGenetics
Volume141
Issue number2
StatePublished - Jan 1 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics

Fingerprint Dive into the research topics of 'Nondisjunction rates and abnormal embryonic development in a mouse cross between heterozygotes carrying a (7, 18) Robertsonian translocation chromosome'. Together they form a unique fingerprint.

Cite this